In TeX Live since 2011, pdftex, pdflatex, and other TeX programs can call a small list of trusted programs during typesetting. For example, these programs are allowed to call Ghostscript to convert eps files to pdf files
It is possible to configure pdftex, pdflatex, and other programs so they can call arbitrary shell commands during typesetting. In that case, the flag "--shell-escape" must be added to the calling sequence, either in the Engine configuration section of TeXShop Preferences or in particular engine scripts. However, this flag is a serious security risk because it allows arbitrary shell programs to run, including for example a short program to erase all files in the home directory. If the flag is set, a malicious web site could offer a TeX source file which erases these files when it is typeset.
Although we recommend against setting the flag, it may be required by a few unusual typesetting packages. TeXShop provides a protection mechanism for this situation. A preference item under the Engine tab is labeled "Shell Escape Warning." This item is off when TeXShop is delivered. If the item is on and "shell-escape" is active, then the first time a file is typeset during a TexShop session, a warning dialog will appear allowing you to turn shell-escape off for that particular file. This dialog will not appear again during the session for that particular file. Thus you can typeset your own files using "shell-escape" and typeset files received in the mail without "shell-escape."